DRP-1

[DAP kinase-related protein-1] This cytoplasmic serine/threonine kinase shows a high degree of homology to DAP kinase. The approved gene symbol is DAPK2 [death-associated protein kinase-2, DAP kinase 2].

DRP-1-beta is an alternatively splice isoform that lacks the calmodulin regulatory domain of DRP-1, and instead contains a motife resembling a leucine zipper similar to the protein binding region of ZIPK. This isoform retains the biochemical and cellular properties that are common to DRP-1 and ZIPK but in addition can bind to the ATF4 transcription factor like ZIPK. This isoform is expressed in embryonic mouse ... ... ... ...
 
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Entry last modified: May 2017