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DRP-1

[DAP kinase-related protein-1] This cytoplasmic serine threonine kinase shows a high degree of homology to DAP kinase. The approved gene symbol is DAPK2 [death-associated protein kinase-2, DAP kinase 2].

DRP-1-beta is an alternatively splice isoform that lacks the calmodulin regulatory domain of DRP-1, and instead contains a motife resembling a leucine zipper similar to the protein binding region of ZIPK. This isoform retains the biochemical and cellular properties that are common to DRP-1 and ZIPK but in addition can bind to the ATF4 transcription factor like ZIPK. This isoform is expressed in embryonic mouse ... ... ... ... ... Subscribe to continue reading! ... ...

 

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