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DOL54

[downstream of the liposarcoma-associated fusion oncoprotein 54] The gene encoding this protein has been cloned cloned as a downstream target gene of the FUS-DDIT3 chimera, which is the fusion gene that characterizes myxoid liposarcoma. DOL54 expression is activated in primary fibroblasts by the expression of the TLS-CHOP oncoprotein, a fusion between the transcription factor gadd153 and the N-terminus of an RNA-binding protein TLS/FUS.

The DOL54 protein is associated closely with adipogenic differentiation. DOL54 overexpression in Chinese hamster ovary cells yields cells that grow as tumors in nude mice ... ... ... ... ... Subscribe to continue reading! ... ...

 

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