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DLC2

[deleted in liver cancer 2] The approved gene symbol is STARD13 [START domain-containing protein 13].

Ching et al (2003) have identified DLC2. The gene is related to DLC1 and encodes a Rho family GTPase-activating protein (GAP). The protein contains a RhoGAP domain (hence the designation START-GAP2), a SAM domain, and a lipid-binding StAR-related lipid transfer domain (START domain). Ng et al (2006) have reported mitochondrial targeting of DLC2. Kawai et al (2009) have localized DLC2 in focal adhesions where it competes with DLC1 in focal adhesion targeting.

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