DEK

(approved gene symbol) DEK is a highly conserved oncogene identified first as part of a fusion protein resulting from a t(6;9) translocation found in a subset of patients with acute myelogenous leukemia (von Lindern et al, 1992, 1992). The DEK protein is conserved widely among species and is transcribed at high levels, especially in hematopoietically derived cells (von Lindern et al, 1992, 1992, 1992). Fu et al (1997) have identified DEK as pets factor, so named because it binds to the pets (peri-ets) enhancer region, which is found in many isolates of HIV-1 and is required together with neighbouiring sitges for HIV-2 enhancer activation in T-cells

The terms DEK1 [DEK isoform 1 ... ... ... ...
 
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Entry last modified: February 2022