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DEFB123

[Beta-Defensin-123] DEFB123 is a Beta-Defensin with antimicrobial activity against a broad spectrum of Gram-positive bacteria and Gram-negative bacteria. The gene has been characterized by Radhakrishnan et al (2005).

DEFB123 has been shown to prevent TNF-alpha secretion in a murine monocyte cell line (RAW264.7) treated with bacterial lipopolysaccharides and can prevent mortality in C57BL/6 mice induced by LPS (Motzkus et al, 2006). These authors have suggested that the physiological role may include interference with LPS action on macrophages ... ... ... ... ... Subscribe to continue reading! ... ...

 

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