DARPP-32

[dopamine and cAMP regulated phosphoprotein 32 kDa] Another designation is PPP1R1B [protein phosphatase 1 regulatory subunit 1B].

DARPP-32 is an enzyme expressed widely in neurons of the central nervous system (Ouimet et al, 1984; Ouimet and Greengard, 1990; Walaas and Greengard, 1984), amacrine cells of the retina (Partida et al, 2004), but also in granulosa luteal cells and ovary (Mayerhofer et al, 1999), parathyroid hormone producing cells of the human parathyroid gland (Meister et al, 1991), and pancreatic Beta-cells (Lilja et al, 2005).

The human gene has been cloned by Brene et al (1994) and encodes a protein of 204 amino acids. ... ... ... ... ... Subscribe to continue reading! ... ...