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D-box

[destruction box] This sequence motif, RxxLxxI/VxN, is a degradation signal (degron) found in cyclins and other proteins that are targeted for degradation by the anaphase-promoting complex or cyclosome (APC/C), a large E3 RING-cullin ubiquitin ligase assembled from 13 different proteins that controls sister chromatid segregation and the exit from mitosis by catalysing the ubiquitylation of these target proteins, which are then marked for degradation through the ubiquitin proteasome system (Glotzer et al, 1991; Burton et al, 2005; Hilioti et al, 2001; for general overview see also: Barford, 2011).

For information on other protein domains and sequence motifs see also the Protein domains/sequence motifs Dictionary section of this encyclopedia.

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