Cytokine network

This term essentially refers to the extremely complex interactions of cytokines by which they induce or suppress their own synthesis or that of other cytokines or their receptors, and antagonize or synergise with each other in many different and often redundant ways. regulatory peptide factors and a variety of low molecular weight substances are also part of this complex system. Another element of complexity in the cytokine network is introduced by the fact that many genes encoding cytokines can give rise to variant forms of cytokines by means of alternative splicing, yielding molecules with slightly different but biologically significant bioactivities.

These interactions often resemble Cytokine cascades with one cytokine initially triggering the expression of one or more other ... ... ... ...
 
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Entry last modified: March 2002