Cystatin-7

approved gene symbol CST7. This protein is a member of the cystatin superfamily of the papain family of cysteine proteases (Rawlings and Barrett, 1990; Brown and Dziegielewska, 1997). It is known also as Cystatin F (Ni et al, 1998), CMAP [cystatin-like metastasis-associated protein] (Morita et al, 1999), or leukocystatin (Halfon et al, 1998).

Cystatin-7 is a secreted protein. Cystatin-7 is secreted as a disulphide-linked dimer. Targetting to endosomes within the cells requires modification of the N-terminus (Cappello et al, 2004). The recombinant protein reversibly inhibits papain and cathepsin L.

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Entry last modified: March 2012