CRF2-s1 |
CRF2X |
Transcription factor A, mitochondrial |
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[cytokine receptor family type 2 soluble-1] abbr. CRF2-s1. This protein is a member of the cytokine receptor family type 2. CRF2 soluble 1 is an exclusively soluble receptor. Two splice variants (CRF2-s1-long, 263 amino acids; and CRF2-s1-short, 231 amino acids) have been described (Gruenberg et al, 2001).
The gene is not expressed in resting or in populations of stimulated leukocytes. CRF2-s1-long is only expressed in placenta. CRF2-s1-short is expressed in the placenta and also in human mammary gland and, at a lower level, in skin, spleen, thymus and stomach.
Sequence analysis shows that the protein is identical with IL22RA2 [interleukin-22 receptor-alpha-2; IL22R-alpha-2]. The protein acts as a soluble antagonist of
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