CHAK

[CC-Chemokine-activated killer] A name given to cytolytic cells similar to cells activated by IL2 (see: LAK cells).

CD4(+) or CD8(+) cells do not generate CHAK activity. CHAK activity is obtained by incubating CD56(+) cells with certain members of the CC-Chemokines (MIP-1-alpha, MIP-1-beta, MCP-1, and RANTES). IL8 does not induce CHAK activity. The presence of other cell types, such as cells expressing CD4 or CD8, is necessary to induce the proliferation of ... ... ... ...
 
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Entry last modified: January 2007