CD318

Other designations:

CDCP1 [CUB domain containing protein 1]

SIMA135 [subtractive immunization M(+)HEp3 associated 135 kDa protein]

TRASK [transmembrane and associated with src kinases]

CD318 has been shown to be involved in cell adhesion, anchorage, and cell migration, in particular in various types of cancer cells where it plays a role in tumor progression and metastasis. These processes involve phosphorylation of the protein. It is also a marker for subsets of immature hematopoietic stem cells, is expressed in leukemic blasts, and appears to play a role in early erythropoiesis (see: CDCP1).

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