CCDC134

[coiled-coil domain containing 134] This protein of 229 amino acids has been identified by Huang et al (2008) as a secreted protein that inhibits activation of extracellular signal-regulated kinase ERK and mitogen-activated kinase JNK [c-jun N-terminal kinase] (MAPK8), but not p38 MAPK.

Huang J et al (2014) have reported that CCDC134 acts as an immune cytokine. CCDC134 promotes CD8(+) T-cell activation, proliferation, and cytotoxicity by augmenting expression of the T-cell effector molecules IFN-gamma, TNF-alpha, granzyme B, and perforin. CCDC134 facilitates infiltration of ... ... ... ...
 
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Entry last modified: October 2019