BmICE-2

[Bombyx mori ICE-2; Bombyx mori IL1-beta Convertase-2] BmICE-2 is a pro-apoptotic caspase involved in cell death by apoptosis in the silkworm Bombyx mori (Yi et al, 2014). Recombinant BmICE-2 cleaves the synthetic human initiator caspase-9 substrate LEHD-pNA, but shows little activity towards the effector caspase-3 substrates DEVD-pNA. Transient expression of BmICE-2 in silkworm cells triggers caspase-3-like protease activity and causes cell death. This effect is not seen in Spodoptera frugiperda 9 cells.

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Entry last modified: January 2014