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BORA

[Bone-derived osteoclast recruiting activity] This biochemically uncharacterized factor has been isolated from bovine bone. It copurifies with osteogenin but is not identical with osteogenin or TGF-beta. The factor promotes the formation of osteoclasts. BORA primarily causes the differentiation of osteoclast precursors and does not stimulate osteoclast function in vitro resorption assays with disaggregated rat osteoclasts.

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