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BCNP1

[B-cell novel protein 1]; approved gene symbol: FAM129C [Family with sequence similarity 129 member C]. In some databanks the term Niban-like protein 2 has been used as a recommended name. This protein has been identified by Boyd et al (2003). It shows highest expression in lymph node and spleen, with little to no expression in other tissues, including other hemopoietic tissues. Expression is high in B-cell malignancies.

Hong R et al (2019) have identified BCNP1 as a B-cell receptor signaling molecule. Overexpression of BCNP1 in immature B-cells potentiates apoptosis induced by alpha-IgM, whereas silencing of its expression reduces it.

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Entry last modified: September 2023



 
 
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