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BCL1

(bcl stands for B-cell lymphoma) A cell line established from a spontaneous lymphoma obtained from a female BALB/c mouse. This murine B-lineage leukemia has many features of human CLL (chronic lymphocytic leukemia). Cells are passaged as spleenic tumors in vivo and isolated from the tumor by Ficoll gradient centrifugation and depletion of T-cells with monoclonal antibodies.

In vitro the cell line can be induced by bacterial endotoxins to produce IgM. The cells express IgM and also IgD on the cell surface.

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