BB-10010
BB-10010 is a mutein of MIP-1-alpha that carries a single amino acid substitution of Asp26 > Ala and, unlike the parent compound, shows a reduced tendency to form large polymers at physiologic pH and ionic strength (Hunter et al, 1995).
BB-10010 acts as a human MIP-1-alpha-like agonist in receptor binding, calcium mobilization, inhibition of colony formation, and thymidine suicide assays. The myeloprotective activity of BB-10010 has been shown in a murine model of repeated chemotherapy using hydroxyurea. BB-10010 has been shown in mice to block the entry of hematopoietic stem cells into the S phase of the cell cycle and to increase their self-renewal capacity during recovery from cytotoxic damage.
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