BANF1

[Barrier to autointegration factor 1] abbr. also BAF [Barrier to autointegration factor]. BANF1 is an evolutionarily conserved DNA-binding protein identified originally for its role in preventing destructive autointegration of retroviral genomes (Lee and Craigie, 1998; Lin and Engelman, 2003). BANF1 is required to segregate and enclose chromosomes within the nuclear envelope and to assemble the nuclear lamina (Margalit et al, 2005) and plays a role in the formation of the nuclear envelope during cell cycle progression (Margalit et al, 2007). The importance of BANF1 in development is illustrated by the observation that knock-down of the expression of BANF1 homologs during the early stages of Drosophila or Caenorhabditis elegans ... ... ... ...
 
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Entry last modified: August 2014