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This cell line is a non-Burkitt B-lymphoma cell line established by Lok et al (1979) from the pleural effusion of a patient with a poorly differentiated diffuse lymphocytic lymphoma. The cells lack the Epstein-Barr virus genome and have abnormal chromosome constitutions including a 14q+ marker. They express surface immunoglobulin isotypes (gamma and chi chain determinants), and Ia-like B-cell-associated antigen.

BALM-4 cells have been used to assay IL4 (see also: bioassays, cytokine assays) (Calklard et al, 1988; Shields et al, 1987). The activity of the factor is determined by measuring the incorporation of tritiated thymidine into the newly synthesized DNA of proliferating cells ... ... ... ... ... Subscribe to continue reading! ... ...


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