B8R

[Vaccinia virus B8R protein] A protein encoded by the B8R open reading frame of vaccinia virus. B8R possesses a hydrophobic amino-terminal signal sequence but lacks a discernible membrane anchor domain, suggesting that the proteins may be secreted. B8R has sequence similarity to the extracellular binding domain of cellular IFN-gamma receptors and binds IFN-gamma.

Expression of the B8R gene appears to affect virulence. In rabbits, skin lesions produced by virus mutants lacking B8R are smaller and tend to disappear earlier than those caused by wild-type virus (Sroller et al, 2001). Vaccinia virus vectors with an inactivated B8R gene are attenuated in vivo without a concomitant reduction in immunogenicity (Verardi et al, 2001). The IFN-gamma ... ... ... ...
 
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Entry last modified: March 2002