Autophagin-4 |
autophagolysosomes |
prodynorphin(207-223) |
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[autophagin]
Autophagins constitute a family of 4 putative cysteine proteinases cloned by Marino et al (2003). These proteins are similar to Apg4/Aut2, a yeast enzyme involved in the formation of autophagosomes during autophagy. Autophagins are broadly distributed in human tissues, being especially abundant in skeletal muscle. Human autophagin-1 and autophagin-3 have been shown to complement the deficiency in the yeast protease, restoring the phenotypic and biochemical characteristics of autophagic cells.
Autophagin-1 is known also as ATG4B or
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