Arginine-vasotocin |
Argininosuccinate synthase |
biliary glycoprotein |
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approved gene symbol: ASS1 [Argininosuccinate synthase 1]; abbr. also: ASS [Argininosuccinate synthase]. Argininosuccinate synthetase, called also Citrulline-aspartate ligase (EC6.3.4.5), is involved in the conversion of citrulline and aspartate to argininosuccinate (Husson et al, 2003; Haines et al, 2011). The enzyme catalyzes the rate-limiting step in the biosynthesis of arginine, which plays a role in the synthesis of urea, nitric oxide, polyamines, proline, glutamate, creatine and agmatine (Morris, 2006).
Role in cancer
Loss or reduced expression of argininosuccinate synthetase has been observed in a subset of human cancers. These cells
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