Angiopoietin-2

abbr. Ang-2, ANGPT2. Angiopoietin-2 (496 amino acids) is related to Angiopoietin-1 and was identified by homology screening (Maisonpierre et al, 1997). The human gene has been mapped to chromosome 8p23 (Cheung et al, 1998). Several Angiopoietin-2 isoforms with truncated amino-terminal domains arising by alternative splicing have been described. Ang-2(443) is a shorter form of Angiopoietin-2(443 amino acids) from human umbilical vein endothelial cell cDNA and lacks a part of the coiled-coil domain (amino acids 96-148) in the amino-terminal region of Angiopoietin-2. This shorter protein is expressed in primary endothelial cells, several nonendothelial tumor ... ... ... ...
 
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Entry last modified: March 2006