ASTN2
[astrotactin-2] This protein has been identified by Wilson et al (2010). The structure of ASTN2 with a unique combination of polypeptide folds has been reported by Ni et al (2016). A mechanism for membrane recognition or secondary messenger regulation of its activity is suggested by the observation that ASTN-2 (but not ASTN-1) binds inositol triphosphates.
ASTN2 is expressed at high levels in migrating, cerebellar granule neurons, along with ASTN1 [Astrotactin-1], at developmental stages when glial-guided migration is ongoing. ASTN2 forms a complex with ASTN1 and regulates surface expression of ASTN1. The cDNA has been identified independently as KIAA0634.
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