ADAM1b |
ADAM3 |
cerebellar vermis defect |
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[ADAM metallopeptidase domain 2; a disintegrin and metalloprotease domain 2] This protein is known also as Fertilin-beta (FTNB; previously known as PH-30-beta) (Vidaeus et al, 1997; Gupta et al, 1996). The protein is a member of the ADAM protein family (Waters and White, 1997). In some databanks, ADAM2 is being referred to as CT15 [Cancer/testis antigen 15].
Fertilin-beta is a cysteine-rich surface membrane glycoprotein found on the head region of spermatozoa. It has been implicated in sperm-egg binding and membrane fusion.
The protein interacts with integrin-alpha-6 / integrin-beta-1
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