virokinin

This peptide is released from the fusion protein F of the Pneumovirus Bovine respiratory syncytial virus, which, together with the large attachment protein G, mediates binding of virus to cells. Fusion protein F is responsible also for fusion of viral and cell membranes. The F protein, which is indispensable for virus replication and processed into a 2 subunit fusion-active by endoprotease furin. This processing step also releases an N-glycosylated peptide of 27 amino acids (pep27) (Gonzalez-Reyes et al, 2001; Zimmer et al, 2001). pep27 is further subjected to post-translational modifications and is converted into virokinin (GIPELIHYTRNSTKKFYGLMamide; Gly-Ile-Pro-Glu-Leu-Ile-His-Tyr-Thr-Arg-Asn-Ser-Thr-Lys-Lys-Phe-Tyr-Gly-Leu-Met), which is a member of the ... ... ... ...
 
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Entry last modified: June 2014