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vav-2

[vav guanine nucleotide exchange factor 2; guanine nucleotide exchange factor vav2] Murine Vav2, the second member of this subfamily of GDP-GTP exchange factors displays 63 % homology to Vav1, but is more widely expressed, also in non-hematopoietic tissues (Schuebel et al, 1996; Denkinger et al, 2000).

Vav-2 and the related genes vav-1, and vav-3 share a conserved domain structure: an amino-terminal calponin homology domain, followed by an acidic region, a catalytic Dbl homology domain involved in the guanine nucleotide exchange reaction, a pleckstrin homology domain, a zinc finger domain, a SH2 domain and two ... ... ... ... ... Subscribe to continue reading! ... ...

 

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