shuchin 5 |
Shv |
NUC |
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Shuchins constitute a family of antimicrobial peptides isolated from skin secretions of the frog, Rana shuchinae that lives in freezing mountains. The two known family members are shuchin 1 (NALSMPRNKCNRALMCFG) and shuchin 2 (NALSSPRNKCDRASSCFG) (Zheng et al, 2010).
Synthetic shuchins show strong and broad antimicrobial activities against Gram-positive bacteria (Staphylococcus aureus, and Bacillus cereus), Gram-negative bacteria (Escherichia coli, Bacillus dysenteriae, Pseudomonas aeruginosa), and yeast (Candida albicans), but no hemolytic activity under the effective concentration.
Pei et al (2013) have described and cloned
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