regucalcin

abbr. and approved gene symbol: RGN; abbr. sometimes RC. Regucalcin was identified originally as a calcium-binding protein from rat liver (Yamaguchi and Yamamoto, 1978). It differs from calmodulin and other calcium-related proteins and plays a regulatory role in calcium-dependent and -independent signaling processes in various tissues and cell types (for overview see: Yamaguchi M, 2005, 2011).

This protein has been identified independently as SMP30 [senescence marker protein-30], a distinctive protein the expression of which in the liver, kidney, and lung decreases in an androgen-independent manner with aging (Fujita et al, 1992). The gene has been cloned by Fujita et al (1995) (for overview see also: Fujita, 1999) and its sequence is highly conserved in ... ... ... ...
 
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Entry last modified: September 2014