poly-arginine

also: oligoarginine. This term pertains to synthetic stretches of arginine residues (L-isoforms or D-isoforms, that are resistant to proteolysis), most commonly Octa-arginine (Arginine-octamer) (RRRRRRRR; abbr. often R8) or Nona-arginine (Arginine-nonamer, sometimes Nonarginine) (RRRRRRRRR; abbr. often R9), but also shorter and longer constructs (Rn, n=7-16; Futaki et al, 2001, 2001; Alhakamy and Berkland, 2013). Poly-arginine residues have the capacity to internalize into cells and penetrate biological membranes. Octa-arginine shows very similar translocation characteristics to HIV-1 ... ... ... ...
 
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Entry last modified: September 2017