PHLDA2 |
pHLIP variant 3 |
EC1.4.4.2 |
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[pH low insertion peptide] pHLIP is a cell-penetrating peptide with pH-dependent transmembrane ability. It is derived from the C-helix of the integral membrane protein bacteriorhodopsin. The sequence, HNGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT contains a transmembrane domain (WARYADWLFTTPLLLLDLALLV) with titratable acidic residues that are responsible for fully reversible pH-dependent transmembrane activity (Hunt et al, 1997). The term often referred to as WT-pHLIP (for wild-type pHLIP) is used frequently for the sequence ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT. Weerakkody et al (2013 have reported the design of 16 pHLIP peptide
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