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lymphangioblasts

[lymphangioblast]

Lymphangioblasts are mesenchymal cells that give rise, at least in part, to lymphatic vessels. Lymphangioblasts express the homeobox transcription factor Prox1 (Rodriguez-Niedenführ et al, 2001), which is a master control gene in the program specifying lymphatic endothelial cell fate (Hong et al, 2002). Mice deficient for this homeobox transcription factor are practically devoid of lymphatics (Wigle and Oliver, 1999; Wigle et al, 2002). Wilting and Becker (2006) have suggested the existence of two types of lymphangioblasts. Type 1 is derived from venous endothelium, while type 2 originates from mesenchymal precursor cells.

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