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karyolysis

this term refers to the dissolution of cell nuclei in dying cells. In Hematoxylin and Eosin stains a very early sign of karyolysis may be a lessening of nuclear basophilia, i.e., less staining with hematoxylin. Karyolysis is usually followed by pyknosis, a shrinking of the nucleus that is associated with an increase of nuclear basophilia.

For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.

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