fms
The cellular c-fms oncogene is the cellular homolog of a viral oncogene called v-fms, which is encoded by SM-FeSV (Susan McDonough strain of Feline sarcoma virus).
fms encodes a transmembrane protein consisting of an extracellular ligand-binding domain of 512 amino acids, a transmembrane region of 25 amino acids, and a cytoplasmic domain of 435 amino acids. The cytoplasmic domain encoded a tyrosine-specific protein kinase activity. The human fms gene consists of 21 small exons interrupted by introns ranging in size from 6.3 kb to less than 0.1 kb.
fms is expressed on cells of the
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