Wnt-3a |
Wnt-5a |
RING finger homologous to inhibitor of apoptosis protein |
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[Wnt family member 4; wingless-type MMTV integration site family member 4] Wnt-4 is one member of the so-called Wnt family of proteins (Nusse et al, 1991), identified by Gavin et al (1990) by virtue of sequence homology to Wnt-1.
Lyons et al (2004) have identified frizzled-6 as a receptor for Wnt-4. These authors have suggested also the existence of other Wnt-4 receptors. Wnt-4 has been implicated in a variety of biological processes.
Stark et al (1994) have reported high expression of Wnt-4 in kidney mesenchyme and its derivatives. Wnt-4 is required for kidney tubulogenesis and appears to act as an autoinducer of the mesenchyme-to-epithelial transition that underlies nephron development. Knock-out mice
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