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Wnt-3

[Wnt family member 3; wingless-type MMTV integration site family member 3] Wnt-3 is one member of the so-called Wnt family of proteins (Nusse et al, 1991). The human homolog of mouse Wnt-3 has been cloned by Roelink et al (1993). Comparison of the deduced mouse and human Wnt-3 protein sequences show 4 changes in 333 amino acids. Wnt-3 has been identified originally as int-4, a chromosomal site of insertion of mouse mammary tumor virus (MMTV) on human chromosome 17q21 (Roelink et al, 1990, 1993; Rider et al, 1989).

Huguet et al (1994) have reported expression of Wnt-3 in breast cell lines and in breast tissue.

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