Wispostatin-1

Wispostatin-1 is a bioactive fragment (see also: cryptides) derived from the WISP-1 [Wnt-1 induced secreted protein-1; Wnt1-inducible signaling pathway protein-1] gene. Wispostatin-1 (SPWSPCSTSCGLGVSTRI; Ser-Pro-Trp-Ser-Pro-Cys-Ser-Thr-Ser-Cys-Gly-Leu-Gly-Val-Ser-Thr-Arg-Ile) corresponds to residues 221-238 of WISP-1 (WISP-1(221-238)). Wispostatin-1 has been shown to inhibit the proliferation and migration of human umbilical vein endothelial cells in vitro and is therefore thought to possess anti-angiogenic properties in vivo (Karagiannis and Popel, 2008). Cano Mdel V et al (2009) have reported that Wispostatin-1 inhibits ocular neovascularization ... ... ... ...
 
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Entry last modified: April 2013