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Vap

[Vascular Associated Protein] This zebrafish type 1 transmembrane protein, which affects erythropoiesis and angiogenesis, has been identified by Kawahara et al (2012). The primary structure of Vap shows no obvious similarity to known genes in GenBank, and presently it is not clear whether a mammalian homolog exists.

Vap is expressed predominantly in the intermediate cell mass of the embryo and enriched subsequently in endothelial cells. Knock-down of Vap expression decreases the numbers of erythrocytes and also strongly suppresses hemoglobin production. Vap knock-down also causes irregular branching of the intersegmental vessels. Knock-down ... ... ... ... ... Subscribe to continue reading! ... ...

 

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