VLL-28

VLL-28 peptide (VLLVTLTRLHQRGVIYRKWRHFSGRKYR) is a cryptic peptide contain within the sequence of Stf76 protein, a transcription factor encoded by pSSVx, a hybrid plasmid-virus from the archaeon Sulfolobus islandicus (Contursi P et al, 2014).

Notomista E et al (2015) have reported that VLL-28 displays chemical, physical, and functional properties typical of cationic antimicrobial peptides and possesses broad-spectrum antibacterial activity.

VLL-28 is active against Gram-positive bacteria and Gram-negative bacteria including some clinically relevant strains, such as Pseudomonas aeruginosa and Staphylococcus aureus, and is active also against Candida albicans. In Escherichia coli, the activity of VLL-28 is comparable to that of ... ... ... ...
 
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Entry last modified: March 2016