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VISDEDGVTH

(Val-Ile-Ser-Asp-Glu-Asp-Gly-Val-Thr-His) This peptide has been identified in Ruditapes philippinarum fermented with Bacillus natto. It acts as a competitive inhibitor of angiotensin-1 converting enzyme (CD143). The peptide is resistant against digestion with gastrointestinal proteases. An in vivo study in rats shows a significant anti-hypertension effect of the peptide. VISDEDGVTH enhances the release of NO and scavenges reactive oxygen species in human vascular endothelial cells (Chen Y et al, 2018).

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Entry last modified: September 2020

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