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VIM-2 is the designation of a mouse monoclonal antibody specific for human blood cells of myelomonocytic lineage (Macher et al, 1988). The antibody binds to a series of minor gangliosides isolated from the cells of patients with chronic myelogenous leukemia (Uemura et al, 1985).

Immunoreactive gangliosides have been identified as a ceramide decasaccharide, VIII3NeuAcV3-Fuc-nLc8Cer and a ceramide dodecasaccharide X3-NeuAcVII3Fuc-nLc10Cer. Immunostaining with the VIM-2 antibody of gangliosides from normal human neutrophils, acute myeloid leukemia, and chronic myelogenous leukemia cells suggests that expression levels are related to the level of ... ... ... ... ... Subscribe to continue reading! ... ...


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