VDTTD |
VDVAD-AFC |
monostratified amacrine cells |
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The synthetic peptide VDVAD (Val-Asp-Val-Ala-Asp) conjugated to 7-amino-4-trifluoromethyl coumarin (VDVAD-AFC) is a fluorogenic substrate for caspase-2 which is detectable following cleavage of the substituted coumarin moiety from the peptide (Talanian et al, 1997). Although caspase-2 efficiently cleaves peptides containing the sequence VDVAD, caspase-3 can cleave these peptides with similar kinetics (Talanian et al, 1997). This lack of specificity associated VDVAD-based substrates that do not allow to distinguish between caspase-2 and caspase-3
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