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UL7

[Cytomegalovirus UL7 protein] This gene is encoded by an open reading frame within the genome of human cytomegalovirus (Dolan et al, 2004). The sequence of UL7 is highly conserved across different CMV genotypes (Sekulin et al, 2007). UL7 is a heavily glycosylated transmembrane protein with an Ig-like domain that exhibits remarkable amino acid similarity to CD229, a cell surface molecule involved in leukocyte activation. Engel et al (2011) have reported that UL7 can mediate adhesion to dendritic cells, is constitutively shed from the cell surface of infected cells, and attenuates the production of pro-inflammatory cytokines TNF-alpha, IL8, and IL6 in ... ... ... ... ... Subscribe to continue reading! ... ...

 

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