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U-box

The U-box is a modified RING finger motif found in various eukaryotic proteins (Johnson et al, 1995; Koegl et al, 1999; Aravind and Koonin, 2000). The U-box is a domain of approximately 70 amino acids without the full complement of Zn ion binding ligands. The U-box domain can interact directly with several E2 enzymes of the ubiquitination pathway and is thought to function similar to the RING finger motif in the ubiquitin-conjugating system (Pringa et al, 2001). The U-box is of ancient origin (Marin, 2010), and members of the U-box family of proteins constitute a distinct class of ubiquitin-protein ligases. They interact with molecular chaperones or cochaperones, including Hsp90, Hsp70, DnaJc7, EKN1, CRN ... ... ... ... ... Subscribe to continue reading! ... ...

 

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