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TsMIF

[Trichinella spiralis macrophage migration inhibitory factor] This is a homolog of mammalian MIF encoded by Trichinella spiralis and Trichinella pseudospiralis. The protein 57 % identity with the MIF encoded by Trichuris trichiura (TmMIF) and 44 % with the MIF encoded by Brugia malayi (Bm-MIF). It displays 41 % homology with human MIF and 40 % homology with that of murine MIF (Wu et al, 2003).

Vaccination with a DNA vaccine co-expressing TsMIF and TsMCD-1 [T. spiralis cystatin-like domain protein] have been show to increasee levels of the Th1 cytokine (IFN-gamma ... ... ... ... ... Subscribe to continue reading! ... ...

 

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