TRIM3 |
TRIM5-alpha |
casein-alpha-s2(198-202) |
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[tripartite motif-containing protein 5] This protein, a member of a large family of proteins containing a tripartite motif, has been identified together with many other TRIM family members by Reymond et al (2001). In databanks the protein is known also as RNF88 [RING finger protein 88]. A number of splice variants of TRIM5 have been described (Reymond et al, 2001; Brennan et al, 2007; Battivelli et al, 2011). TRIM5-alpha [tripartite motif-containing protein 5-alpha] is the best studied isoform, and its activity can be influenced by the presence of other isoforms (Battivelli et al, 2011).
Cellular factors expressed in many mammalian cell types that restrict the replication of N-tropic
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