TRAP-2

[TNF receptor-associated protein 2] This protein of 97 kDa has been shown to bind to the intracellular domain of the type 1 TNF receptor (Dunbar et al, 1997).

TRAP-2 has been shown to be identical with subunit 2 of the 26S proteasome complex (PSMD2), called p97 by Tsurumi et al (1996), which mediates the degradation of constitutively short-lived proteins, regulatory proteins, and abnormal and malfolded proteins. The PSMD2 subunit has been cloned by Boldin et al (1995), who called it 55.11, and suggested that interaction of the proteasome subunit with the TNF receptor may be responsible for its short half-life.

Strassar et al (1999) have reported that TRAP-2 expression is downregulated in renal carcinoma ... ... ... ...
 
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Entry last modified: December 2004