TMEM77 |
TMEM100 |
GFER |
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[Transmembrane protein 98] Wu et al (2015) have reported that TMEM98 is a type 2 transmembrane protein. TMEM98 is expressed widely in most tissues with particularly high expression in the ovary, pancreas, and prostate. Wu et al (2015) have shown that the protein can also be secreted through exosomes. TMEM98 is secreted in full length and not through cleavage. The protein is found in supernatants of activated but not resting peripheral blood mononuclear cells. Its expression is upregulated during the activation and differentiation of Th1 cells. Recombinant TMEM98 promotes Th1 cell differentiation both in vitro and in vivo.
Lv et al (2017) have reported that TMEM98 expression significantly increases in endothelial cells and
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