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TLTYTWS

This peptide (Thr-Leu-Thr-Tyr-Thr-Trp-Ser) has identified in a phage display screen for peptides that bind specifically to proteolytically processed collagen-4. TLTYTWS specifically binds to collagen-4 modified by matrix metalloproteinase MMP-2. TLTYTWS is a tumour homing peptide that accumulates in tumours but not in control organs. TLTYTWS inhibits angiogenesis in an in vivo assay in a concentration-dependent manner and significantly reduces endothelial differentiation in vitro.

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Entry last modified: March 2015

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